Soulcatcher tells the story of a young, smart and sexy widow who comes to New Orleans, "the most haunted city in America", in search of the ghost of her dead husband. Instead, she discovers that she has the power to absorb the abilities of the recently dead - and uncovers a mystery that the spirit world would kill to protect.

In the first issue, the widow Roma Canto meets Chris Lockman, the latest in a long line of "witchfinders", guardians since ancient times. Chris can see the ghosts around every corner, and as he guides Roma through the city, he begins to realize that the ghosts are gunning for her!